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A timeline of key discoveries in genetics: from Darwin to The Human Genome Project

Genetics as we know and understand it today has been shaped, over decades, by the work of many dedicated scientists around the world, and they all deserve our praise and recognition.

To illustrate how the field of genetics has evolved, we have selected some key breakthroughs to highlight in our latest infographic. As you read through them, remember there are many more not included here, and that ground-breaking discoveries often build on the research that came before. The achievements we have listed here bring us up to 2022, but it is not the end of the story, and as research in the field of genetics continues, we are excited to see what the future holds.

You can read more about the contributions of female scientists to the field of genetics in one of our other infographics.

In this infographic:

  • 1859 Survival of the fittest
  • 1865 Laws of inheritance
  • 1869 DNA isolated for the first time
  • 1882 Chromosomes discovered
  • 1902 First genetic disease documented
  • 1909 First use of the word “gene”
  • 1910 First sex linked trait discovered
  • 1951 First amino acid sequence published
  • 1953 Structure of DNA described
  • Early 1960s First newborn screening test
  • 1975 DNA sequencing methods developed
  • 1982 GenBank opened
  • 1985 Polymerase chain reaction developed
  • 1985 DNA fingerprinting developed
  • 1990 Human genome project launched
  • 1998 Mycobacterium tuberculosis genome sequenced
  • 1999 Chromosome 22 sequenced
  • 2000 Draft of the human genome published
  • 2002 Complete mouse genome sequenced
  • 2003 Human Genome Project completed
  • 2020 Genome of strains of novel SARs-CoV-2 virus sequenced
  • 2022 Remaining gaps in the human genome sequenced
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References

The infographic was compiled using information from the following sources:

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“Genetic Timeline” National Human Genome Research Institute, Genome.gov, https://www.genome.gov/Pages/Education/GeneticTimeline.pdf. Accessed 11 Oct. 2023.

Pickrell, John. “Timeline: Genetics.” New Scientist.com, https://www.newscientist.com/article/dn9966-timeline-genetics/. Accessed 12 Oct. 2023.

Britannica, The Editors of Encyclopaedia. “Friedrich Miescher”. Encyclopedia Britannica, updated 22 Aug. 2023, https://www.britannica.com/biography/Friedrich-Miescher. Accessed 09 Nov. 2023.

Lamm, Ehud et al. “Before Watson and Crick in 1953 Came Friedrich Miescher in 1869.” Genetics vol. 215,2 (2020): 291-296. doi:10.1534/genetics.120.303195, https://pubmed.ncbi.nlm.nih.gov/32487691/.

“The discovery of DNA.” Yourgenome.org, 21 Jul. 2021, https://www.yourgenome.org/stories/the-discovery-of-dna/. Accessed 11 Oct. 2023.

Zacharias, Helmut. “Famous scholars from Kiel: Walther Flemming” Christian-Albrechts-Universität zu Kiel, https://www.uni-kiel.de/grosse-forscher/index.php?nid=flemming&lang=e. Accessed 09 Nov. 2023.

Britannica, The Editors of Encyclopaedia. “Walther Flemming”. Encyclopedia Britannica, last updated 31 Jul. 2023, https://www.britannica.com/biography/Walther-Flemming. Accessed 09 Nov. 2023.

“Alkaptonuria.” NHS, last reviewed 10 Mar 2022, https://www.nhs.uk/conditions/alkaptonuria/. Accessed 09 Nov. 2023.

“Thomas H. Morgan – Facts.” NobelPrize.org. Nobel Prize Outreach AB 2023, https://www.nobelprize.org/prizes/medicine/1933/morgan/facts. Accessed 11 Oct. 2023.

Jeffers, Joe Stewart. “Frederick Sanger”. Encyclopedia Britannica, last updated 09 Aug. 2023, https://www.britannica.com/biography/Frederick-Sanger. Accessed 9 Nov. 2023.

“GenBank Celebrates 25 Years of Service with Two-Day Conference; Leading Scientists Will Discuss the DNA Database at April 7-8 Meeting.” National Institutes of Health, 3 Apr. 2008, https://www.nih.gov/news-events/news-releases/genbank-celebrates-25-years-service-two-day-conference-leading-scientists-will-discuss-dna-database-april-7-8-meeting. Accessed 11 Oct. 2023.

“Kary B. Mullis – Facts.” NobelPrize.org. Nobel Prize Outreach AB 2023. https://www.nobelprize.org/prizes/chemistry/1993/mullis/facts/. Accessed 12 Oct. 2023.

“What is a DNA fingerprint?” Yourgenome.org, 21 Jul. 2021, https://www.yourgenome.org/facts/what-is-a-dna-fingerprint/. Accessed 11 Oct. 2023.

Britannica, The Editors of Encyclopaedia. “DNA fingerprinting”. Encyclopedia Britannica, 07 Oct. 2023, https://www.britannica.com/science/DNA-fingerprinting. Accessed 12 October 2023.

“Human Genome Project. Fact Sheet.” National Human Genome Research Institute, Genome.gov, 24 Aug. 2022, https://www.genome.gov/about-genomics/educational-resources/fact-sheets/human-genome-project. Accessed 11 Oct. 2023.

“1998: M. Tuberculosis Bacterium Sequenced.” NIH National Human Genome Research Institute, last updated 28 May 2013, https://www.genome.gov/25520389/online-education-kit-1998-m-tuberculosis-bacterium-sequenced. Accessed 10 Nov. 2023.

Gröschel, Matthias I et al. “Pathogen-based precision medicine for drug-resistant tuberculosis.” PLoS pathogens vol. 14,10 e1007297. 18 Oct. 2018, doi:10.1371/journal.ppat.1007297. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193714/?report=reader. Accessed 10 Nov. 2023.

“Tuberculosis (TB) Whole Genome Sequencing.” CDC Centers for Disease Control and Prevention, last updated 02 May 2022, https://www.cdc.gov/tb/programs/genotyping/genome-sequencing.htm. Accessed 10 Nov. 2023.

1999: Chromosome 22.” NIH National Human Genome Research Institute, last updated 28 May 2013 https://www.genome.gov/25520396/online-education-kit-1999-chromosome-22. Accessed 10 Nov. 2023.

Mayor, S. “First human chromosome is sequenced.” BMJ (Clinical research ed.) vol. 319,7223 (1999): 1453A. doi:10.1136/bmj.319.7223.1453a, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1117192/. Accessed 10 Nov. 2023.

Dunham, I et al. “The DNA sequence of human chromosome 22.” Nature vol. 402,6761 (1999): 489-95. doi:10.1038/990031, https://www.nature.com/articles/990031. Accessed 10 Nov. 2023.

“2002: Mouse Genome Sequenced.” National Human Genome Research Institute, 15 Aug. 2013, https://www.genome.gov/25520486/online-education-kit-2002-mouse-genome-sequenced. Accessed 11 Oct. 2023.

“Mouse Genome Project.” Broad Institute, https://www.broadinstitute.org/mouse/mouse-genome-project. Accessed 11 Oct. 2023.

Ganguly, Prabarna and Zisk, Rachael. “Researchers generate the first complete, gapless sequence of a human genome” National Human Genome Research Institute, 31 Mar. 2022, https://www.genome.gov/news/news-release/researchers-generate-the-first-complete-gapless-sequence-of-a-human-genome. Accessed 11 Oct. 2023.

“SARS-CoV-2 Sequencing Data: The Devil Is in the Genomic Detail.” American Society for Microbiology, 28 Oct. 2022, https://asm.org/Articles/2020/October/SARS-CoV-2-Sequencing-Data-The-Devil-Is-in-the-Gen. Accessed 11 Oct. 2023.

“All Nobel Prizes in Physiology or Medicine.” NobelPrize.org. Nobel Prize Outreach AB 2023. https://www.nobelprize.org/prizes/lists/all-nobel-laureates-in-physiology-or-medicine. Accessed 11 Oct. 2023.

“All Nobel Prizes in Chemistry.” NobelPrize.org. Nobel Prize Outreach AB 2023. https://www.nobelprize.org/prizes/lists/all-nobel-prizes-in-chemistry. Accessed 11 Oct. 2023.

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