top-banner

METHODS AND TECHNOLOGIES

Microsatellite Analysis

MICROSATELLITE ANALYSIS

Microsatellites (MS) are non-coding regions of DNA that are found throughout the genome, characterized by the repetition of specific sequence motifs in varying lengths. Every individual carries two copies (alleles) of each microsatellite in their nucleated cells, which can differ in length depending on whether they originate from the mother or father. The pattern of microsatellite lengths across multiple loci constitutes an individual’s genetic fingerprint, which is unique for every person except identical twins. By analyzing several microsatellites simultaneously, a unique DNA profile can be created for an individual within a population group, with an accuracy exceeding 99.999999%. Comparing microsatellite patterns between individuals, combined with established biostatistical methods, allows for highly reliable determination or exclusion of biological relationships. Microsatellite analysis is also widely applied in forensics and to rule out contamination in prenatal diagnostics.

Microsatellites also play an important role in various tumor diseases. Their repetitive structure makes them prone to a high mutation rate, which can result in microsatellite instability (MSI) in tumors. MSI refers to the presence of microsatellites with altered lengths that are not found in the corresponding germline DNA, typically caused by defects in the DNA mismatch repair (MMR) system. Variants in MMR genes can lead to faulty DNA replication during cell division in tumor tissues, producing variable microsatellite lengths detectable as MSI. Determining and detecting MSI is not only important for diagnosing and classifying tumors but also provides valuable prognostic and therapeutic insights.

WAYS TO PARTNER WITH US

TarCET IVD Kits

CE-IVD kits containing reagents
for hereditary indications in
an easy-to-use kit form

Learn more

Technology Transfer

Out-of-the-box genetics workflow
from sequencing to reporting
for non-invasive prenatal testing

Learn more

Genetic Testing Laboratory

Your partner for
all genetic tests

Learn more

Contact Us

Please get in touch with us
for any questions, inquiries,
feedback, or with any
comments you might have.

Learn more

BLOG ARTICLES

February, designated as Cancer Awareness Month, marks a time to reflect on the remarkable progress made in cancer research and to inspire hope for th…

Read more

Introduction Cardiovascular disease (CVD) is a major health issue as it remains a leading cause of death worldwide [1]. CVD is responsible for mor…

Read more

Antimicrobial resistance (AMR) is one of the most pressing global health threats, and accurate identification and surveillance of multidrug-resistant…

Read more

Colorectal cancer remains a significant health concern globally. While genetic factors play a crucial role in its development, identifying the exact …

Read more

A new meta-analysis links trans-kingdom gut microbiota (bacteria, eukaryotes, viruses, archaea) to immune checkpoint inhibitor (ICI) response in canc…

Read more

Reproductive health is a fundamental aspect of human well-being, affecting individuals and communities worldwide [1]. It encompasses a wide range of …

Read more

It seems as though everyone is talking about artificial intelligence, usually referred to as AI, these days! Indeed, not only are AI tools now access…

Read more

Orphan drugs are those developed specifically for the treatment of rare diseases. Within the pharmaceutical industry, the drug development process is…

Read more

A study of 629 pregnancies with ultrasound-detected anomalies found that exome sequencing identified pathogenic variants in 14% of cases. The detecti…

Read more

Breast cancer is a type of cancer that originates in the breast cells. Genetic changes in the DNA of the healthy breast cells can lead to the formati…

Read more

OUR NETWORK