NeoThetis: Breast / Gynecological

Synonyms: -
Material
Material:
Blood in STRECK tube
Untersuchungsdauer
TAT:
6-9 days
Contact
Methode
Method:
NGS
Overview

NeoThetis Breast/Gynaecological panel can test for genetic alterations which are commonly found in gynaecological cancers such as breast, ovarian and others. Different risk factors, such as inheritance, increasing age, and environmental factors, can contribute to the development of gynaecological cancers. This panel identifies the genetic mutations in 48 genes in circulating tumour DNA, which can help in therapy selection and re-evaluation. There are numerous /-approved therapies for gynaecological cancers depending on the type of cancer.

Microsatellite instability (MSI) immunotherapy biomarker is also tested in this panel. The approved immunotherapy drug pembrolizumab is available for treating patients with MSI-high status. Pembrolizumab has also been approved by the for endometrial cancer.

NeoThetis: Breast / Gynecological
48 Gene(s)*
AKT1
ATM
BARD1
BRAF
BRCA1
BRCA2
BRIP1
CHEK2
CTNNB1
DICER1
EGFR
ERBB2
ERBB3
ESR1
FBXW7
FGFR1
FGFR2
FGFR3
FOXA1
FOXL2
GATA3
KIT
KRAS
MAP3K1
MET
MLH1
MRE11
MSH2
MSH6
MTOR
NBN
NRAS
NTRK1
NTRK2
NTRK3
PALB2
PIK3CA
PIK3CB
PMS2
POLE
PTEN
RAD51C
RAD51D
RAF1
RET
RUNX1
SMAD4
TP53


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