NeoThetis: Pan-Cancer Plus

Synonyms: -
Material
Material:
Blood in STRECK tube
Untersuchungsdauer
TAT:
6-9 days
Contact
Methode
Method:
NGS
Overview

NeoThetis Pan-Cancer Plus panel analyses 222 genes associated with different types of cancers. It can help identify genetic alterations that can be responsible for cancer development and therapy resistance in solid tumours. The clinical significance of the genes tested has been previously emphasised by professional bodies including and . Depending on the type of cancer and the genetic alterations identified, different /-approved drugs as well as eligible clinical trials are available.

Microsatellite instability (MSI) immunotherapy biomarker is also tested in this panel. / approved immunotherapies, such as pembrolizumab, are also available for patients with MSI-high status depending on their type of cancer.

Blood-based Tumour Mutational Burden (bTMB) immunotherapy biomarker is also tested in this panel. bTMB is tumour agnostic and is applicable for all solid tumours, including rare types. It can guide healthcare providers to identify patients who might benefit from immunotherapy.

NeoThetis: Pan-Cancer Plus
222 Gene(s)*
ABL1
ABL2
AKT1
AKT2
ALK
ANKRD26
APC
AR
ARAF
ASXL1
ATM
ATRX
B2M
BAP1
BARD1
BCL2
BCL6
BCOR
BCORL1
BCR
BMPR1A
BRAF
BRCA1
BRCA2
BRIP1
CALR
CBFB
CBL
CBLB
CBLC
CCND1
CCND2
CCND3
CCNE1
CD274
CD74
CDC25C
CDH1
CDK12
CDK4
CDK6
CDKN2A
CEBPA
CHEK2
CIC
CSF1R
CSF3R
CTLA4
CTNNB1
CUX1
CXCR4
DCK
DDR2
DDX41
DEK
DHX15
DICER1
DNMT3A
DUSP22
EGFR
EIF1AX
EPCAM
ERBB2
ERBB3
ERBB4
ERCC4
ERG
ESR1
ETNK1
ETV1
ETV4
ETV6
EWSR1
EZH2
FANCA
FBXW7
FGF13
FGF19
FGF2
FGF3
FGFR1
FGFR2
FGFR3
FGFR4
FLT1
FLT3
FLT4
FOXA1
FOXL2
FOXO1
FRS2
FUBP1
GATA1
GATA2
GATA3
GNA11
GNAQ
GNAS
H3F3A
HDAC2
HOXB13
HRAS
IDH1
IDH2
IKZF1
IL3
INHA
INSRR
IRF4
JAK1
JAK2
JAK3
KDM6A
KDR
KEAP1
KIT
KMT2A
KMT2C
KMT2D
KRAS
LUC7L2
MALT1
MAP2K1
MAP2K2
MAP3K1
MDM2
MECOM
MET
MITF
MLH1
MLLT3
MPL
MRE11
MSH2
MSH6
MTOR
MUTYH
MYC
MYCN
MYD88
MYH11
MYOD1
NBN
NCOA3
NF1
NF2
NFE2L2
NOTCH1
NPM1
NRAS
NRG1
NTRK1
NTRK2
NTRK3
NUP214
NUTM1
PALB2
PARP1
PBX1
PDCD1
PDCD1LG2
PDGFRA
PDGFRB
PGR
PHF6
PIK3CA
PIK3CB
PIK3R1
PML
PMS2
POLD1
POLE
PPM1D
PPP2R1A
PTCH1
PTEN
PTPN11
RAD21
RAD51C
RAD51D
RAF1
RARA
RB1
RBBP6
RET
RNF43
ROS1
RPS14
RUNX1
RUNX1T1
SETBP1
SF3B1
SH2B3
SLC29A1
SMAD4
SMARCA4
SMARCB1
SMC1A
SMC3
SMO
SOX10
SPOP
SRSF2
STAG2
STAT3
STAT5B
STK11
SUZ12
TCF3
TCL1A
TERT
TET2
TMPRSS2
TP53
TSC1
TSC2
U2AF1
VEGFA
VHL
WT1
XPO1
ZRSR2


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Our editorial team consists of medical specialists and scientists in the field of human genetics. All content is created and reviewed in accordance with current scientific standards.

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