NeoThetis: Pancreatic

Synonyms: -
Material
Material:
Blood in STRECK tube
Untersuchungsdauer
TAT:
6-9 days
Contact
Methode
Method:
NGS
Overview

Pancreatic cancer is a malignancy arising from the cells of the pancreas and ranks as the 12th most common cancer worldwide. Despite its relatively low incidence, it is characterized by high mortality and is among the leading causes of cancer-related death globally, ranking third in several developed countries. Cancer initiation and development are characterised by the accumulation of genetic mutations that cause the cancer cells to divide uncontrollably. Examples of genes that have been found to be mutated in patients with pancreatic cancer include KRAS, ALK, and BRCA1, among others. /-approved drugs are available to target pancreatic cancer, depending on the molecular profile of the tumour and the mutated genes present in each patient. One example is olaparib in BRCA-mutated metastatic pancreatic cancer.

Testing for microsatellite instability (MSI) immunotherapy biomarker is also included in this panel, and can expand the treatment opportunities with the -approved immunotherapy drug pembrolizumab for patients with MSI-high status.

NeoThetis: Pancreatic
26 Gene(s)*
ALK
ATM
BRAF
BRCA1
BRCA2
CDKN2A
CHEK2
ERBB2
FBXW7
FGFR1
FGFR2
FGFR3
KRAS
MLH1
MSH2
MSH6
MYC
NTRK1
NTRK2
NTRK3
PALB2
PMS2
ROS1
SMAD4
STK11
TP53


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