NeoThetis: Prostate

Synonyms: -
Material
Material:
Blood in STRECK tube
Untersuchungsdauer
TAT:
6-9 days
Contact
Methode
Method:
NGS
Overview

Prostate cancer arises from the cells in the prostate gland, and it is the 2nd most common cancer in men. Prostate cancer manifests from the accumulation of mutations that cause the healthy cells of the prostate to transform into malignant cells and divide uncontrollably.  The cancer cells will then form a tumour mass that will ultimately spread to nearby organs in a process known as metastasis.

This panel identifies the genetic mutations in 35 genes in the circulating tumour DNA that is released from prostate cancers. Screening for the mutations responsible for cancer progression enables the identification of FDA/EMA-approved therapies tailored to each patient with prostate cancer.

Microsatellite instability (MSI) immunotherapy biomarker has also been detected in patients with prostate cancer, and it can be used as an immunotherapy biomarker for men with advanced prostate cancer. The FDA-approved drug pembrolizumab can be used as an immunotherapy option for MSI-high patients.

NeoThetis: Prostate
35 Gene(s)*
AKT1
APC
AR
ATM
BARD1
BRAF
BRCA1
BRCA2
CHEK2
CTNNB1
ERBB2
FGFR1
FGFR2
FGFR3
FOXA1
MLH1
MSH2
MSH6
MYC
MYCN
NRAS
NTRK1
NTRK2
NTRK3
PALB2
PIK3CA
PIK3CB
PMS2
POLE
PTEN
RAD51C
RAD51D
SPOP
TMPRSS2
TP53


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