PGx irinotecan

Synonyms: Irinotecan (Campto, Camptosar; liposomal Onivyde), UGT1A1, UGT1A1 genotyping

Material:

EDTA blood
(1 ml), buccal swab

TAT:

3-5 days

Method:

qPCR

Overview

Irinotecan is a topoisomerase-I inhibitor used to treat several solid tumours. UDP-glucuronosyltransferase 1A1 (UGT1A1) inactivates its active metabolite SN-38, and reduced-function UGT1A1 genotypes raise the risk of severe toxicity. This analysis determines UGT1A1 metaboliser status from the *6 and *28 alleles and reports the diplotype with the derived phenotype. It assesses the gene-to-drug relationship only and gives no dosing recommendation.

PGx irinotecan

1 Gene(s)*

UGT1A1

Pharmacological background

Tested variants

Result interpretation

The result is reported as the UGT1A1 diplotype and the metaboliser phenotype derived from it. For UGT1A1 the phenotype is assigned directly from the function classes of the two alleles, not from a numeric activity score.

Serious, life-threatening adverse events occur more often in poor metabolisers.

Phenotype	Genotype	Description
Normal metaboliser	1/1	Normal UGT1A1 activity
Intermediate metaboliser	1/6, 1/28	Reduced UGT1A1 activity
Poor metaboliser	6/6, 28/28, 6/28	Markedly reduced activity; increased SN-38 exposure

Test limitations

Clinical relevance

Indication	ICD-10	Gene	OMIM
Adverse drug reaction	T88.7	UGT1A1	191740

References

Created by

Our editorial team consists of medical specialists and scientists in the field of human genetics. All content is created and reviewed in accordance with current scientific standards.

Last content review: August 4, 2026. As pharmacogenomic evidence and recommendations continue to evolve, the information presented on this page may not always reflect the latest updates. For current guidance and annotations, please refer to .

Last Update : 24.09.2026

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