PGx siponimod

Synonyms: Mayzent, CYP2C9, CYP2C9 genotyping

Material:

EDTA blood
(1 ml), buccal swab

TAT:

3-5 days

Method:

qPCR

Overview

Siponimod is used to treat active secondary progressive multiple sclerosis, with relapses or imaging features of inflammatory activity. It is metabolised principally by the polymorphic enzyme CYP2C9, so its systemic exposure depends strongly on CYP2C9 genotype. The EU product information therefore requires CYP2C9 genotyping before treatment is started, because siponimod is contraindicated for one CYP2C9 genotype and its use in others is subject to a genotype-dependent restriction.

PGx siponimod

1 Gene(s)*

CYP2C9

Pharmacological background

Tested variants

Result interpretation

Test limitations

Clinical relevance

Indication	ICD-10	Gene	OMIM
Adverse drug reaction	T88.7	CYP2C9	601130

References

Created by

Our editorial team consists of medical specialists and scientists in the field of human genetics. All content is created and reviewed in accordance with current scientific standards.

Last content review: August 4, 2026. As pharmacogenomic evidence and recommendations continue to evolve, the information presented on this page may not always reflect the latest updates. For current guidance and annotations, please refer to .

Last Update : 24.09.2026

How to order a genetic test

Select the right test for your patients. Contact our team in case you do not have an active contract yet.

Collect the sample. Download and fill in the order and consent form or access our portal (available for sample sent to Germany).

Properly pack the sample and send it to Medicover Genetics.

The sample will be analysed in our accredited laboratories.

An actionable report will be available for you to access safely and securely.

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