TarCET Kits

As demand for molecular diagnostics continues to expand across multiple clinical specialties, laboratories require flexible, scalable, and efficient NGS workflows that support a growing test portfolio without increasing operational complexity.

The TarCET Kits portfolio enables laboratories to:

• Expand molecular diagnostic testing across multiple clinical disciplines
• Standardise laboratory workflows using a universal library preparation and targeted protocols
• Multiplex compatible assays within the same sequencing run through cross-indication multiplexing
• Maximise sequencing capacity and instrument utilisation
• Streamline laboratory operations with compatible workflows and proprietary bioinformatics
• Scale testing capabilities to meet evolving clinical and business needs

Whether implementing a single targeted assay or building a comprehensive molecular diagnostics service, TarCET Kits provide laboratories with a flexible, standardised solution designed for routine clinical implementation.

TarCET Kits are built on a universal targeted sequencing workflow designed to support routine molecular diagnostics across multiple clinical applications. Combining library preparation, targeted capture enrichment, and proprietary bioinformatics, the workflow delivers a standardised, reproducible approach to targeted NGS testing.

Designed for flexibility and scalability, the TarCET workflow enables laboratories to implement multiple assays using universal laboratory protocols, reducing operational complexity while supporting consistent analytical performance. Compatible with Illumina and Element Biosciences sequencing platforms, TarCET Kits integrate seamlessly into existing laboratory infrastructure and are suitable for laboratories of any throughput.

Built around a universal workflow, TarCET Kits provide laboratories with the flexibility to expand their molecular diagnostics portfolio while maintaining standardised processes, simplified training, and efficient laboratory operations.

• Universal workflow architecture
  The TarCET portfolio is designed around a harmonised laboratory workflow. While PGT applications have specific sample preparation requirements, all assays converge into a common target capture enrichment and sequencing workflow, simplifying implementation, training, and routine laboratory operations.
• Cross-indication multiplexing
  Combine compatible TarCET assays within the same sequencing run to maximise sequencing capacity, improve instrument utilisation, and increase operational efficiency.
• Broad clinical portfolio
  A comprehensive range of multi-gene assays supporting reproductive health, preimplantation genetic testing (PGT), carrier screening, neonatal and postnatal disorders, hereditary cancer, cardiovascular diseases, metabolic disorders, infertility, and oncology.
• Flexible laboratory implementation
  Validated manual workflows provide an efficient solution for laboratories with lower throughput or those seeking to minimise capital investment, while automation-compatible workflows support higher throughput laboratories and future operational scaling.
• High throughput & scalability
  Supports laboratories of any throughput, with multiplexing capabilities of up to 384 reactions per sequencing run*.
• Flexible sample processing
  Compatible with genomic DNA (gDNA) extracted from human cells, including whole blood and buccal swab, across most assays, with dedicated workflows for blastomere and blastocyst biopsies in PGT applications.
• Simplified laboratory workflow
  Designed to improve laboratory efficiency through streamlined protocols, reduced equipment requirements, flexible fragmentation options, and reduced sequencing output requirements for selected assays.
• Multi-platform compatibility
  Validated on Illumina and Element Biosciences sequencing platforms.
• Proprietary bioinformatics
  Integrated proprietary bioinformatics supporting standardised data analysis for variant calling and reproducible laboratory workflows.
• Clinical interpretation tool compatibility
  Medicover Genetics has partnered with VarSome Clinical, an IVDR-certified platform for gene annotation and variant interpretation of genes tested with TarCET assays. VarSome Clinical is available as an add-on (analysis tokens) to TarCET customers upon request.

*Panel and platform dependent

TarCET Kit is a reagent kit including library preparation and targeted capture enrichment. The kit is intended for use with genomic DNA extracted from human cells for library preparation and target capture enrichment for next-generation sequencing (NGS) applications. It enables the targeting of specific genomic regions using validated DNA hybridisation probe panels supplied with the kit. Downstream analysis may be performed using the IVD VEGA analysis software (not included with the kit) or an independent IVD analysis software, in accordance with the intended use.

Whether implementing a single clinical application or progressively expanding into additional specialties, the TarCET portfolio enables laboratories to build a comprehensive molecular diagnostics service using harmonised workflows, compatible sequencing infrastructure, and a common implementation approach.

TarCET Kits are designed to integrate seamlessly into existing molecular diagnostics laboratories, providing the flexibility to support different operational models, throughput requirements, and sequencing platforms.

Validated for use on:

• Illumina sequencing platforms
• Element Biosciences sequencing platforms

Whether operating a manual workflow or an automated laboratory environment, TarCET Kits support efficient implementation while maintaining standardised laboratory processes and analytical performance.

From laboratories implementing their first targeted NGS assay to high-throughput molecular diagnostics centres, TarCET Kits provide a scalable solution that grows with your testing portfolio and operational requirements.

TarCET Kits are engineered to support efficient implementation, consistent analytical performance, and scalable laboratory operations across a broad range of molecular diagnostic applications.

Workflow

• Harmonised library preparation and target capture enrichment workflow
• Streamlined laboratory protocol
• Universal workflow architecture across the TarCET portfolio
• Compatible with manual and automation-ready laboratory workflows

Sample types

• Blood and buccal swab specimens (assay dependent)
• Dedicated workflows for blastomere and blastocyst biopsies in PGT applications

Sequencing

• Validated on Illumina and Element Biosciences sequencing platforms
• Multiplexing capability of up to 384 reactions
• Reduced sequencing output requirements for selected assays

Laboratory performance

• Automation compatible
• Flexible fragmentation options, including mechanical and enzymatic methods
• Simplified workflow with reduced equipment requirements
• Mean coverage uniformity ≥20×: >97%

Bioinformatics

• Proprietary bioinformatics
• Compatible with our own VEGA analysis software or independent IVD analysis software
• Integrated sample management through SIRIUS
• Standardised data analysis and reporting workflows

Integrated software solutions

TarCET Kits are supported by Medicover Genetics’ proprietary software and bioinformatics ecosystem, providing laboratories with a streamlined pathway from sequencing data to meaningful genetic insights.

Designed to complement the TarCET workflow, our software solutions support sample management, data analysis, variant interpretation, and results visualisation, helping laboratories simplify routine operations while maintaining consistent and reproducible analysis.

Laboratories have the flexibility to perform downstream analysis using Medicover Genetics’ proprietary software solutions or an independent IVD analysis software, depending on their operational and regulatory requirements.

Genetic data management

SIRIUS is a genetic data management application that enables laboratories to organise sequencing runs, manage sample batches, and visualise analysis results through intuitive dashboards, graphs, and tabular reports.

Analysis software

VEGA is an IVD bioinformatics analysis software designed to analyse NGS data generated by the TarCET workflow. It supports the detection and classification of clinically relevant genetic variants across the intended applications of the TarCET portfolio.

Together, SIRIUS and VEGA provide an integrated software environment that supports efficient laboratory operations, standardised data analysis, and scalable implementation across multiple clinical applications

TarCET Kits are developed and manufactured under robust quality management systems to support the delivery of reliable and consistent molecular diagnostic solutions.

The portfolio comprises CE-marked, IVDR-compliant, NGS-based multi-gene kits designed for library preparation and targeted capture enrichment across a broad range of molecular diagnostic applications.

Quality standards

• Manufactured under ISO 13485-certified quality management systems
• Developed in accordance with internationally recognised quality standards
• Designed to support consistent analytical performance and laboratory implementation

Regulatory compliance

• CE-marked under the In Vitro Diagnostic Regulation (IVDR) (EU) 2017/746
• Intended for use in conjunction with compatible IVD analysis software, including VEGA or an independent IVD analysis software, in accordance with the intended use of each kit
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Our quality and regulatory framework supports laboratories in implementing TarCET Kits with confidence while maintaining high standards of performance, consistency, and compliance.

Our commitment extends beyond the delivery of TarCET Kits. Medicover Genetics provides comprehensive scientific, technical, and operational support to help laboratories implement, optimise, and expand their molecular diagnostics services with confidence.
Our support services include:

• Technical support and troubleshooting
• Scientific application support
• Workflow implementation guidance
• Laboratory training and competency development
• Protocol verification
• Performance and quality monitoring
• Ongoing product and software updates

Whether implementing your first targeted NGS assay or expanding an established molecular diagnostics laboratory, our team works alongside you to support successful implementation and long-term operational excellence.

Discover how TarCET Kits can help your laboratory simplify targeted NGS implementation, standardise laboratory workflows, and build a scalable molecular diagnostics portfolio across multiple clinical applications.

Whether you are introducing your first targeted assay or expanding an established testing menu, our specialists are ready to help you identify the right solution for your laboratory.