OVERVIEW
Our NGS-based reagents, TarCET Kits, along with their accompanying accessories, UltraVerse Index Oligos, are CE marked and compliant with the In Vitro Diagnostic Regulation (IVDR) (EU) 2017/746. This compliance with the IVDR signifies that our products adhere to rigorous regulatory standards, ensuring both efficacy and patient safety.
Medicover Genetics TarCET Kits offer a wide range of reliable and easy-to-implement genetic testing solutions, providing accurate, fast, and cost-efficient detection of genetic variants only in conjunction with an IVD Analysis Software.
INTENDED USE
TarCET Kit is a reagent kit including library preparation and targeted capture enrichment. The kit is intended for use with genomic DNA from human cells for library preparation and capture enrichment for Next Generation Sequencing (NGS) applications. The kit can be used to target specific regions of the genome with validated DNA hybridization probe panels supplied in the kit. All further downstream analyses can be performed in conjunction with the IVD VEGA analysis software, not provided in this kit, or using an independent IVD analysis software.
TarCET KIT PANELS UPDATES
All TarCET Kit Panels can be combined into a consolidated workflow, by integrating multiple assays into the same sequencing run. With the unique capacity to run multidiscipline genetic tests in a single sequencing run, Medicover Genetics’ TarCET Kit Panels ensure accurate and fast detection of genetic variants with cost and operational efficiencies for laboratories of any throughput capacities.
TarCET Kit operational and technical advancements:
● Flexibility to choose between buccal swab or blood as a specimen type
● Simplification of protocol
● Requires less equipment during enrichment step
● Reduced PCR replicate steps during post-captured PCR process
● Flexibility to select between two fragmentation methods
● Mechanical fragmentation via sonication
● Enzymatic fragmentation via enzymatic digestion
● Increased sample multiplexing capabilities by lowering sequencing output
● Up to 40% lower sequencing output requirement, depending on the assay
Combination example of multidisciplined assays in one single run.
● Comprehensive gene content providing clinically meaningful insights
● User-friendly and reliable workflows and protocols
● Integration of assays offering operational efficiency
● Unified ecosystem, including software solutions and variant calling
● Optional variant annotation and classification using an independent software
FEATURES & SPECIFICATIONS
● Universal protocol for all assays
● Streamlined simple workflow
● Universal sample input requirements
● Automation compatibility
● Scalable for any throughput laboratory
● Specimen type: Buccal swab or blood
● Mean coverage uniformity ≥ 20x: >97%
● Proprietary bioinformatics
● Unique dual-index combinations compatible with all TarCET Kit Panels
TarCET KIT PANELS
A unique and efficient solution to any laboratory throughput to perform multi-disciplinary genetic tests in-house. By combining different assays in one single sequencing run, laboratories can improve turnaround time and reduce operational costs while ensuring high-quality results. Our comprehensive testing approach is ideal for laboratories looking to provide a wide range of high-fidelity genetic tests to their healthcare associates and patients.
TarCET Kit Panels cover the following disciplines:
| Kit | Description |
| TarCET Carrier Screening Core Panel (see more) | Analyzes 19 genes in individuals with unknown carrier status. |
| TarCET Carrier Screening Comprehensive Panel (see more) | Analyzes 228 genes in individuals with unknown carrier status. |
| TarCET Hereditary Cancer Panel (see more) | Analyzes 62 genes and covers 24 cancer predisposing syndromes associated with hereditary cancer. |
| TarCET Infertility Panel (see more) | Analyzes 54 genes in the female infertility panel and 39 genes in the male infertility panel. Structural and numerical abnormalities on sex chromosomes are included in both panels. |
| TarCET Neonatal Panel (see more) | Analyzes 140 genes associated with genetic disorders that manifest in newborns and early childhood, including conditions with a high incidence in the population, potentially treatable or manageable disorders, and diseases that present during infancy, prior to the onset of detrimental, often irreversible symptoms. |
| TarCET Cardiac Comprehensive Panel (see more) | Analyzes 292 genes and covers major inherited cardiovascular disorders. |
| TarCET Cardiomyopathy Panel (see more) | Analyzes 98 genes and covers cardiomyopathy-related inherited cardiovascular disorders. |
| TarCET Arrythmia Panel (see more) | Analyzes 42 genes and covers arrhythmia-related inherited cardiovascular disorders. |
| TarCET Aortopathy Panel (see more) | Analyzes 48 genes and covers aortopathy-related inherited cardiovascular disorders. |
| TarCET Congenital Heart Defects Panel (see more) | Analyzes 80 genes and covers inherited congenital heart defects. |
| TarCET FH, PH and RAS Panel (see more) | Analyzes 11, 11, and 30 genes and covers Familial Hypercholesterolemia (FH), Pulmonary Hypertension (PH) and RASopathy (RAS) related disorders, respectively. |
| TarCET Metabolic Panel (see more) | Analyzes 223 genes and covers major classes of inherited metabolic disorders. |
| UltraVerse Index Oligos Type A/B/C/D | UltraVerse Index Oligos include unique dual index oligos compatible with all TarCET Kit Panels. |
Each TarCET Kit Panel contains reagents for 16 reactions with multiplexing capabilities up to 384 (4 x 96-index kits). Each UltraVerse Index Oligos kit includes 96 reactions.
PROPRIETARY SOFTWARE SOLUTIONS
Our integrated software solutions optimize your diagnostic efforts, improve data management, and accelerate the transition from data generation to actionable insights. You have the flexibility to perform all downstream analyses either in conjunction with our VEGA data analysis software or using an independent IVD analysis software of your choice.
KEY FEATURES
● Effortless Data Management: Our software allows for the easy creation, calculation, and modification of sample batches linked to sequencing runs, ensuring that your genetic data is organized and readily accessible for analysis.
● Advanced Analytical Capabilities: With our robust analytical tools, we can detect genetic variations, including single nucleotide variants, small insertions and deletions, and copy number alterations. This functionality is essential for deriving meaningful insights from complex genetic datasets.
● Intuitive Visualizations: Our solutions provide clear visual representations of analysis results through engaging graphs and tables, making it easier to interpret data and communicate findings effectively.
● Seamless Integration: Designed to complement the TarCET Kit panel assays, our software integrates smoothly into your laboratory workflows, enhancing efficiency and productivity without disrupting established processes.
Experience the transformative power of our comprehensive laboratory solutions.
| Product Name | Catalog Number |
| TarCET Metabolic Panel | ET201-00-2016 |
| TarCET Aortopathy Panel | ET203-00-2016 |
| TarCET Arrhythmia Panel | ET204-00-2016 |
| TarCET Cardiomyopathy Panel | ET205-00-2016 |
| TarCET Congenital Heart Defects Panel | ET206-00-2016 |
| TarCET FH, PH and RAS Panel | ET207-00-2016 |
| TarCET Cardiac Comprehensive Panel | ET210-00-2016 |
| TarCET Hereditary Cancer Panel | ET211-00-2016 |
| TarCET Infertility Panel | ET212-00-2016 |
| TarCET Neonatal Panel | ET213-00-2016 |
| TarCET Carrier Screening Core Panel | ET214-00-2016 |
| TarCET Carrier Screening Comprehensive Panel | ET215-00-2016 |
| UltraVerse Index Oligos Type A | EU100-00-100A |
| UltraVerse Index Oligos Type B | EU100-00-100B |
| UltraVerse Index Oligos Type C | EU100-00-100C |
| UltraVerse Index Oligos Type D | EU100-00-100D |
How to order: customersupport.genetics@medicover.com
SUPPORT
Medicover Genetics offers on-going support to all TarCET Kit customers through dedicated technical support channels. Members of our team are always available to offer technical support on troubleshooting, quality and performance monitoring. Upon request, we provide customer trainings on workflow, protocol, and data analysis in our certified facilities.
Interested to know more?
Learn how Medicover Genetics can enhance your laboratory’s capabilities with our NGS-based genetic testing solutions by contacting us. Request a consultation to explore the advantages of our comprehensive genetic diagnostics offerings and discuss how our tailored solutions can meet your specific needs.
DOCUMENTATION
TarCET kits Instructions for use
UltraVerse Instructions for use
DNA Denaturation Guidelines
TarCET Kits Certificate of Free Sale for Exportation of Medical Products
UltraVerse Index Oligos Certificate of Free Sale for Exportation of Medical Products
SIRIUS User Guide
