SCIENTIFIC BACKGROUND

AKT1, ALK, APC, AR, ARAF, ATM, ATRX, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CDH1, CDKN2A, CHEK2, CIC, CTNNB1, DDR2, DICER1, EGFR, ERBB2, ERBB3, ERBB4, ESR1, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, FOXA1, FOXL2, FUBP1, GATA3, GNA11, GNAQ, GNAS, H3F3A, IDH1, IDH2, JAK2, KEAP1, KIT, KRAS, MAP2K1, MAP3K1, MET, MLH1, MRE11A, MSH2, MSH6, MTOR, MYC, MYCN, NBN, NF1, NPM1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PDGFRA, PIK3CA, PIK3CB, PMS2, POLE, PTEN, RAD51C, RAD51D, RAF1, RB1, RET, ROS1, RUNX1, SMAD4, SPOP, STK11, TERT, TMPRSS2, TP53, 1p/19q codeletion*

*1p/19q codeletion is reported only in the context of glioma diagnosis.

Category:

Scientific Background

The ForeSENTIA Pan-Cancer panel analyses single nucleotide variants, insertions, deletions, copy number alterations, and rearrangements in 80 genes associated with different types of cancers. It can help identify mutations that can be responsible for cancer development and therapy resistance in solid tumors. The clinical significance of the genes tested has been previously emphasized by professional bodies including NCCN and ESMO. Depending on the type of cancer and the genetic alterations identified, different FDA/EMA-approved drugs as well as eligible clinical trials are available.

 

Microsatellite instability (MSI) immunotherapy biomarker is also tested in this panel. FDA/EMA-approved immunotherapies, such as pembrolizumab, are also available for patients with MSI-high status depending on their type of cancer.

 

Recommendations by professional bodies:

ESMO recommends MSI testing via NGS in different types of cancer including colorectal, endometrial, gastric-oesophageal, ovarian, glioblastoma, pancreatic, NSCLC, and melanoma among others (Luchini et al., 2019).

 

References and more information: 

Luchini C, Bibeau F, Ligtenberg MJL, Singh N, Nottegar A, Bosse T, Miller R, Riaz N, Douillard JY, Andre F, Scarpa A. ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach. Ann Oncol. 2019 Aug 1;30(8):1232-1243. doi: 10.1093/annonc/mdz116. PMID: 31056702.

GENES

AKT1, ALK, APC, AR, ARAF, ATM, ATRX, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CDH1, CDKN2A, CHEK2, CIC, CTNNB1, DDR2, DICER1, EGFR, ERBB2, ERBB3, ERBB4, ESR1, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, FOXA1, FOXL2, FUBP1, GATA3, GNA11, GNAQ, GNAS, H3F3A, IDH1, IDH2, JAK2, KEAP1, KIT, KRAS, MAP2K1, MAP3K1, MET, MLH1, MRE11A, MSH2, MSH6, MTOR, MYC, MYCN, NBN, NF1, NPM1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PDGFRA, PIK3CA, PIK3CB, PMS2, POLE, PTEN, RAD51C, RAD51D, RAF1, RB1, RET, ROS1, RUNX1, SMAD4, SPOP, STK11, TERT, TMPRSS2, TP53, 1p/19q codeletion* *1p/19q codeletion is reported only in the context of glioma diagnosis.
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