SCIENTIFIC BACKGROUND

ATM, BRCA1, BRCA2, CDKN1B, CDKN2A, EPCAM*, MLH1, MEN1, MSH2, MSH6, PALB2, PMS2, STK11, TP53, VHL

Scientific Background

The vast majority of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC) and is the 4th leading case of cancer death in Europe, with about 90,000 deaths annually. Pancreatic neuroendocrine tumors (PNETs) are neoplasms that occur infrequently and represent 1-2% of all pancreatic cancers. Environmental factors such as alcohol, obesity and smoking are contributors to PDAC development, as well as old age and family history, with a hereditary component of 10% in all cases diagnosed.

 

 

*CNV analysis only

Genes in bold are recommended by International guidelines, including German expert panels and/or have been more often associated with specific cancers.

GENES

ATM, BRCA1, BRCA2, CDKN1B, CDKN2A, EPCAM*, MLH1, MEN1, MSH2, MSH6, PALB2, PMS2, STK11, TP53, VHL
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