SCIENTIFIC BACKGROUND

MEN1

Category:

Scientific Background

Parathyroid cancer is a rare type of cancer that originates from the cells in parathyroid gland. In the United States, there are less than 100 cases per year. Parathyroid cancer can either be sporadic or inherited. Inherited disorders such as Multiple endocrine neoplasia type 1 can also increase the risk of developing parathyroid cancer.

 

PreSENTIA hereditary Parathyroid cancer panel tests for numerous germline mutations that could cause parathyroid cancers in the future. Identifying germline mutations associated with cancer susceptibility empowers healthcare providers and patients, as it allows them to take better and more informed decisions.

 

Who is this test for?

You should get tested if you meet at least one of the criteria below:

• You have a personal or family history of a hereditary cancer syndrome associated with parathyroid cancer

You have at least two first-degree family members who have had parathyroid tumors

You have a family member that has been diagnosed with a germline mutation associated with cancer susceptibility

 

How many genes are tested in this panel?

1 gene

 

How many hereditary cancer syndromes are associated with this panel?

1 Hereditary cancer syndrome is associated with this panel. This is:

Multiple endocrine neoplasia type 1 (MEN1)

 

References and more information: 

•  The information above was taken by professional bodies such as NCI

•  Wei CH, Harari A. Parathyroid carcinoma: update and guidelines for management. Curr Treat Options Oncol. 2012 Mar;13(1):11-23. doi: 10.1007/s11864-011-0171-3. PMID: 22327883.

•  Ullah A, Khan J, Waheed A, Sharma N, Pryor EK, Stumpe TR, Velasquez Zarate L, Cason FD, Kumar S, Misra S, Kavuri S, Mesa H, Roper N, Foroutan S, Karki NR, Del Rivero J, Simonds WF, Karim NA. Parathyroid Carcinoma: Incidence, Survival Analysis, and Management: A Study from the SEER Database and Insights into Future Therapeutic Perspectives. Cancers (Basel). 2022 Mar 10;14(6):1426. doi: 10.3390/cancers14061426. PMID: 35326576; PMCID: PMC8946517.

 

GENES

MEN1
How to order

LATEST ARTICLES

Have you ever wondered how jet-setting across the globe might affect your gut health? A recent study has dug into this intriguing question, revealing...

Read more

In June 2023, Medicover Genetics attended the 56th conference of the European Society of Human Genetics (ESHG) which took place in Glasgow, Scotland....

Read more

Vitamin D, also known as “the sunshine vitamin”, is a fat-soluble vitamin that helps the body absorb calcium and phosphate, which are essential f...

Read more

Every movement our body makes is controlled by a long, thin, tube-like structure called the “spinal cord”. The spinal cord is part of our nervous...

Read more

Genetic variant databases are vital for interpreting genetic variations in clinical settings and research. However, misclassified variants can create...

Read more

A recent article published by our team in the International Journal of Molecular Sciences [1], aimed to evaluate the prevalence, prognostic and predi...

Read more

A healthy, nutritious and well-balanced diet is always important for a person’s well-being, and it is even more so during pregnancy as the developi...

Read more

The sun is hot and you are sweating. Most of us know how it feels to sweat, and when we sweat. This is a normal bodily response to an increase in tem...

Read more

All about the pancreas The pancreas is a pear-shaped organ that is located at the upper left side of the abdomen, behind the stomach. It has two m...

Read more

The father of genetics is Gregor Mendel. Mendel was an Austrian monk, whose experiments breeding pea plants in the monastery garden led to breakthrou...

Read more