TRIPLE X SYNDROME (TRISOMY X)

Medicover Genetics Editorial Team |
February 17, 2025

Scientifically reviewed | Last updated
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Triple X syndrome is characterized by a trisomy of the X chromosome. Apart from an above-average height, patients may not show any significant physical symptoms.

 

Also called

Triple X syndrome is also known as:

 

  • 47,XXX syndrome
  • Triplo X syndrome
  • Trisomy X
  • XXX syndrome

 

Symptoms

The main symptom is above-average height.

 

Approximately 70% of women are fertile, but some have menstrual irregularities and premature menopause. Intelligence may be 10–15 points below the family average. There may be a delay in speech development. No increased risk of gonosomal aneuploidies has been described for offspring of triple X women.

 

 

Frequency

The prevalence of triple X syndrome is reported to be approximately 1:1,000 in female newborns.

 

Cause

Triple X syndrome is caused by an extra X chromosome. In 98% of patients, trisomy X is found in all cells, while 2% show mosaicism (extra X chromosome is only in some cells).

 

Inheritance

Triple X syndrome is usually not inherited.

 

Diagnosis

The clinical effects are highly variable, and any women with triple X are never diagnosed. Diagnosis is confirmed by karyotype or chromosomal microarray.

 

References

Ogata et al. 2001, J Med Genet 38:1 / Müller-Henbach et al. 1977, Am J Obstet Gynecol 127:211

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FAQ

Can people with triple X syndrome have children? 

How common is triple X syndrome? 

What are the symptoms of triple X syndrome? 

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