SCIENTIFIC BACKGROUND

XXX

Category:

Triple X syndrome, also known as 47,XXX syndrome or trisomy X, is characterized by a trisomy of the X chromosome. Patients do not usually show significant physical symptoms apart from above average height. As the clinical impact is highly variable, many women with triple X are never diagnosed with this chromosomal aberration. About 70% of women are fertile, but some present with menstrual irregularities and premature menopause. Intelligence may be 10-15 points below the family average. Speech development may be delayed. Offspring of triple X women are not found to be at a higher risk for gonosomal aneuploidy.

 

The prevalence of triple X syndrome is reported to be approximately 1:1,000 in female newborns. In 98% of patients, trisomy X is found in all cells, while 2% show mosaicism.

 

References
Ogata et al. 2001, J Med Genet 38:1 / Müller-Henbach et al. 1977, Am J Obstet Gynecol 127:211

GENES

XXX
How to order

LATEST ARTICLES

Have you ever wondered how jet-setting across the globe might affect your gut health? A recent study has dug into this intriguing question, revealing...

Read more

In June 2023, Medicover Genetics attended the 56th conference of the European Society of Human Genetics (ESHG) which took place in Glasgow, Scotland....

Read more

Vitamin D, also known as “the sunshine vitamin”, is a fat-soluble vitamin that helps the body absorb calcium and phosphate, which are essential f...

Read more

Every movement our body makes is controlled by a long, thin, tube-like structure called the “spinal cord”. The spinal cord is part of our nervous...

Read more

Genetic variant databases are vital for interpreting genetic variations in clinical settings and research. However, misclassified variants can create...

Read more

A recent article published by our team in the International Journal of Molecular Sciences [1], aimed to evaluate the prevalence, prognostic and predi...

Read more

A healthy, nutritious and well-balanced diet is always important for a person’s well-being, and it is even more so during pregnancy as the developi...

Read more

The sun is hot and you are sweating. Most of us know how it feels to sweat, and when we sweat. This is a normal bodily response to an increase in tem...

Read more

All about the pancreas The pancreas is a pear-shaped organ that is located at the upper left side of the abdomen, behind the stomach. It has two m...

Read more

The father of genetics is Gregor Mendel. Mendel was an Austrian monk, whose experiments breeding pea plants in the monastery garden led to breakthrou...

Read more