SCIENTIFIC BACKGROUND

PIK3CA, AKT1

Category:

Scientific Background

The ForeSENTIA PIK3CA and AKT1 Gene-Focused Panel tests for single nucleotide variants, insertions and deletions on the PIK3CA and AKT1 genes. PIK3CA and AKT1 are two genes that transcribe two separate protein kinases, PI3K and AKT1 respectively. Both proteins belong to the PI3K/AKT pathway and play an essential role in regulating different signaling pathways and processes in the cells, such as cell division and survival.

 

In cancer, these genes can be mutated leading to aberrant activation of the PI3K/AKT pathway. As a result, this will cause an increase in cell proliferation and cancer progression. Some examples of cancers caused as a result include colorectal, breast, prostate, NSCLC, and others.

 

Different drugs against PIK3CA and AKT1 are currently being studied for their efficacy in different types of tumors. One drug that was approved by FDA and EMA, alpelisib, targets PIK3CA mutations in patients with breast cancer.

 

References and more information: 

Beaver JA, Gustin JP, Yi KH, Rajpurohit A, Thomas M, Gilbert SF, Rosen DM, Ho Park B, Lauring J. PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system. Clin Cancer Res. 2013 Oct 1;19(19):5413-22. doi: 10.1158/1078-0432.CCR-13-0884. Epub 2013 Jul 25. PMID: 23888070; PMCID: PMC3805128.

He Y, Sun MM, Zhang GG, Yang J, Chen KS, Xu WW, Li B. Targeting PI3K/Akt signal transduction for cancer therapy. Signal Transduct Target Ther. 2021 Dec 16;6(1):425. doi: 10.1038/s41392-021-00828-5. PMID: 34916492; PMCID: PMC8677728.

GENES

PIK3CA, AKT1
How to order

LATEST ARTICLES

Aiming to evaluate the role of chromosomal aneuploidy in pregnancy loss, a 2023 study 35 years in the making evaluated the genomic landscape of first...

Read more

Cancer is a complex genetic disease that affects millions of people in the world. It is one of the leading causes of death worldwide, with about ten ...

Read more

Researchers created a detailed map of the placenta during labor. By studying how maternal and fetal cells communicate, they discovered signals in the...

Read more

A recent paper published in Nature Medicine (1) aimed to identify genes and genomic biomarkers which can better predict outcomes and personalized the...

Read more

In honor of the international day of women and girls in science, we interviewed one of our very own, Dr. Evelina Papaioannou. Dr. Evelina Pa...

Read more

Aneuploidies, such as translocations, whole or segmental chromosomal duplications, and deletions, are examples of chromosomal abnormalities that are ...

Read more

Here you can read the winning essays from the first, annual DNA essay competition on the subject of "How unfolding the DNA code can help with precisi...

Read more

Introduction Our voices are as unique as our fingerprints! Although there are people whose voices might sound alike, there are no two voices exact...

Read more

Not everyone likes winter. For people who do not enjoy the cold weather, or having to put on a thick coat to go outside, a winter can be a source of ...

Read more

The month of November, also known as Movember, has been chosen as the month to raise awareness about men’s health. During Movember, men are encoura...

Read more